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2 4-Dichloro-5-methylpyrimidine (CAS # 1780-31-0) Featured duab
  • 2 4-Dichloro-5-methylpyrimidine (CAS # 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine (CAS # 1780-31-0)

Chemical Property:

Molecular Formula C5H4Cl2N2
Molar Mass 163
Qhov ntom 1.39 g / mL ntawm 25 ° C (lit.)
Melting Point 26-28 ° C (lit.)
Boling Point 108-109 ° C / 11 mmHg (lit.)
Flash Point > 230 ° F
Solubility Soluble nyob rau hauv chloroform, ether, ethyl acetate thiab toluene
Vapor Siab 0.079mmHg ntawm 25 ° C
Qhov tshwm sim hmoov rau pob kom tshem tawm cov kua
Xim Dawb los yog xim tsis muaj xim rau yuav luag dawb lossis Yuav luag tsis muaj xim
pKa -2.44 ± 0.29 (Kev kwv yees)
Kev cia khoom Inert huab cua, 2-8 ° C

Product Detail

Khoom cim npe

Risk thiab Safety

Hazard Cov Cim C - Corrosive
Risk Codes 34 – Ua rau kub hnyiab
Kev nyab xeeb piav qhia S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag.
S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg ua tau.)
S27 - Tshem tawm tag nrho cov khaub ncaws tsis huv tam sim ntawd.
UN IDs UN 3261 8/PG 2
WGK Germany 3
TSCA Yog lawm
HS Code 293359 0
Hazard Class 8
Packing Group III

2 4-Dichloro-5-methylpyrimidine (CAS # 1780-31-0) Cov ntaub ntawv

Siv 2, 4-dichloro-5-methylpyrimidine tuaj yeem siv rau hauv kev npaj ntawm 2-fluoro-5-trifluoromethylpyrimidine. 2-fluoro-5-trifluoromethylpyrimidine yog ib qho tseem ceeb nruab nrab rau kev sib txuas ntawm cov kws tshuaj, uas tuaj yeem siv los ua cov fused nplhaib dihydrofuran cov tebchaw, thiab fused nplhaib dihydrofuran compounds tuaj yeem siv los ua G protein txuas nrog receptor GPR119 modulators, rau kev kho mob ntshav qab zib, kev rog thiab dyslipidemia. Tsis tas li ntawd, 2-fluoro-5-trifluoromethylpyrimidine kuj tseem siv tau los ua ib qho nruab nrab hauv kev sib txuas ntawm cov tshuaj rau kev kho mob Alzheimer's disease thiab schizophrenia.
kev npaj 5-methyluracil 75g (0.59mol), phosphorus oxychloride 236g, triethylamine hydrochloride 16.5g (0.12mol), ntxiv rau cov tshuaj tiv thaiv fwj, rhuab mus rau 100 ℃ ~ 110 ℃, reflux cov tshuaj tiv thaiv 5H, txias rau 40 horus ℃, ntxiv phosphorus 8 (piv txwv li 8 phosphate). 1.19 mol), kub kev tiv thaiv kev tiv thaiv 2H. Tom qab ua tiav cov tshuaj tiv thaiv, phosphorus oxychloride tau zoo los ntawm distillation nyob rau hauv lub siab txo, thiab distillation nyob rau hauv lub siab txo tau txuas ntxiv kom tau 88g (0.54mol) ntawm 2, 4-dichloro-5-methylpyrimidine nyob rau hauv ib tug yield ntawm 91.5%.
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