2 4-Difluorobenzoic acid (CAS # 1583-58-0)

Daim ntawv thov

2, 4-difluorobenzoic acid yog cov tshuaj tseem ceeb thiab tshuaj tua kab nruab nrab, xws li 2, 4-difluorobenzoic acid feem ntau yog siv los ua cov tshuaj tua kab mob fluconazole, voriconazole thiab tshuaj tua kab nruab nrab 4-fluorosalicylic acid, tshuaj intermediate 3, 5-difluoroaniline, thiab lwm yam. 2, 4-difluorobenzoic acid kuj tseem siv tau hauv cov kua siv lead ua cov ntaub ntawv, uas muaj qhov zoo ntawm tus nqi siab thiab kev ua lag luam zoo.

Kev npaj

Ntxiv 2, 4-dinitrotoluene thiab dej rau hauv cov hlab ntsha cov tshuaj tiv thaiv, kho tus nqi pH rau 7, do thiab kub rau 75 ° C. Potassium permanganate, magnesium sulfate thiab theem hloov catalyst tau ntxiv rau hauv cov khoom siv. Tom qab ntxiv, txuas ntxiv do thiab hnov ​​​​mob ntawm qhov kub thiab txias li 3 teev. Lim thaum kub thiab ntxuav lub ncuav mog qab zib nrog dej kub. Ua ke cov filtrate, acidify nrog 35% hydrochloric acid rau pH 2-3, muaj ntau cov dawb precipitates tom qab cov crystals tag nrho precipitated, lim, ntxuav, recrystallized, thiab qhuav kom tau dawb crystals li 2,4-dinitrobenzoic acid. . Qhov piv ntawm 2, 4-dinitrotoluene rau poov tshuaj permanganate yog 2.4: 1. Cov khoom lag luam tawm ntawm cov kauj ruam no yog 90.7%.

Ntxiv N, N-dimethylmethylphthalamide rau hauv lub thawv tshuaj tiv thaiv, kub rau 100 ~ 110 ℃, preheat rau 0.5 ~ 1h. Ntxiv qhuav anhydrous poov tshuaj fluoride nyob rau hauv nplawm thiab ua kom qhov kub thiab txias preheated rau 0.5-1h. Tom qab ntawd, 2, 4-dinitrobenzoic acid thiab hexyltrimethylammonium bromide tau ntxiv sai sai rau cov tshuaj tiv thaiv cov hlab ntsha ib zaug, thiab cov cua kub tau txuas ntxiv mus rau 120 ℃, qhov kub thiab txias tau khaws cia thiab cov tshuaj tiv thaiv stirring txuas ntxiv. Tom qab 7h ntawm cov tshuaj tiv thaiv reflux, cov kuab tshuaj yog rov qab los ntawm distillation, thiab tom qab ntawd cov kua tshuaj tiv thaiv yog distilled nrog chav. Cov seem sau tau yog dawb emulsion. Tom qab sawv ntsug rau ib lub sij hawm, lub hom phiaj oily feem hauv qab hauv qab, cov kua ntshiab ntshiab ntawm sab saud yog nchuav, thiab cov roj yog txias rau precipitate dawb crystals kom tau cov khoom crude; Cov khoom siv raw khoom yog recrystallized, Suction pom, ntxuav, thiab ziab kom tau dawb crystals ntawm 2,4-difluorobenzoic acid. Qhov sib piv ntawm 2, 4-dinitrobenzoic acid rau potassium fluoride yog 2.7: 1. Cov khoom lag luam tawm ntawm cov kauj ruam no yog 72.4%.

Taw qhia
2,4-Difluorobenzoic acid yog cov organic compound. Cov hauv qab no yog kev qhia txog cov khoom, kev siv, kev npaj thiab cov ntaub ntawv kev nyab xeeb ntawm 2,4-difluorobenzoic acid:

Zoo:
- Cov tsos mob: 2,4-Difluorobenzoic acid yog dawb crystalline khoom.
- Solubility: Nws yog soluble hauv cov organic solvents xws li ethanol, methanol thiab methylene chloride.

Siv:
- Cov ntaub ntawv kho qhov muag: Nws kuj tuaj yeem siv los ua ib qho ntawm cov khoom siv raw rau kev npaj cov khoom siv kho qhov muag thiab cov yeeb yaj kiab kho qhov muag.
- Cov ntawv thov kev lag luam: 2,4-difluorobenzoic acid tuaj yeem siv rau hauv kev lag luam hluav taws xob, txheej thiab plastics kev lag luam nrog kev tiv thaiv corrosion, tiv thaiv oxidation thiab tiv thaiv ultraviolet.

Txoj kev:
- 2,4-Difluorobenzoic acid tuaj yeem tau txais los ntawm fluorination ntawm hydrofluoric acid nrog p-methylanisole.

Cov ntaub ntawv kev nyab xeeb:
- Thaum ua haujlwm, plua plav yuav tsum zam kom tsis txhob nqus pa thiab qhov muag. Nyob rau tib lub sijhawm, qhov cua zoo yuav tsum tau khaws cia.
- Tsis txhob sib cuag nrog cov tshuaj oxidizing muaj zog lossis cov kua qaub muaj zog kom tsis txhob muaj kev phom sij txaus ntshai