2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS # 865363-93-5)
Taw qhia 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), ib tug groundbreaking nucleoside analog uas yog teem rau revolutionize lub teb ntawm molecular biology thiab kev tshawb fawb tshuaj. Qhov kev sib xyaw tshiab no yog tsim los txhim kho kev nkag siab ntawm nucleic acid kev sib cuam tshuam thiab cov txheej txheem ntawm tes, ua rau nws yog ib qho cuab yeej tseem ceeb rau cov kws tshawb fawb thiab cov kws tshawb fawb tib yam.
2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine yog tus cwj pwm los ntawm nws cov kev hloov kho tshwj xeeb, uas suav nrog cov ethynyl thiab fluorine hloov pauv ntawm 4′ thiab 2′ txoj haujlwm, feem. Cov kev hloov kho no tsis tsuas yog txhim kho cov kev ruaj ntseg thiab bioavailability tab sis kuj txhim kho nws lub peev xwm nkag mus rau hauv cellular daim nyias nyias, ua rau kom muaj txiaj ntsig zoo dua thiab nce ntxiv hauv ntau yam kab mob lom.
Qhov no nucleoside analog tau pom muaj peev xwm ua tau zoo hauv ntau daim ntawv thov, suav nrog kev tshawb fawb tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob. Nws muaj peev xwm ua raws li cov nucleosides ntuj thaum nthuav tawm cov khoom sib txawv biochemical ua rau nws yog tus neeg sib tw zoo tshaj plaws rau kev txhim kho cov tshuaj kho tshiab. Cov kws tshawb fawb tuaj yeem siv 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine los kawm RNA thiab DNA synthesis, tshawb xyuas kev sib cuam tshuam enzyme, thiab tshawb nrhiav cov txheej txheem ntawm kev ua ntawm cov tshuaj uas twb muaj lawm.
Ntxiv nrog rau nws cov ntawv thov kev tshawb fawb, qhov sib xyaw no kuj tau npaj los ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov kev kho tshiab tiam tom ntej. Los ntawm kev muab kev nkag siab rau nucleic acid tus cwj pwm thiab kev sib cuam tshuam, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine tuaj yeem pab tsim cov kev kho mob zoo dua thiab tsom rau ntau yam kab mob.
Hauv cov ntsiab lus, 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) yog ib qho kev txiav-ntug nucleoside analog uas muaj cov sijhawm tsis sib xws rau kev tshawb fawb thiab kev loj hlob hauv molecular biology thiab pharmacology. Txais lub neej yav tom ntej ntawm kev tshawb pom kev tshawb fawb nrog qhov tshwj xeeb qhov sib xyaw no thiab qhib qhov muaj peev xwm tshiab hauv koj qhov kev tshawb fawb.
