4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile (CAS # 189956-45-4)

Molecular Formula	C11H8N4O
Molar Mass	212.21 Nws
Qhov ntom	1.31 ± 0.1 g / cm3 (Kev kwv yees)
Melting Point	> 300 ° C
Boling Point	399.7 ° C ntawm 760 mmHg
Flash Point	195.6°C dej
Solubility	DMSO (me ntsis), Methanol (me ntsis)
Vapor Siab	0-0Pa ntawm 20-25 ℃
Qhov tshwm sim	Khoom
Xim	Pale Brown rau Brown
pKa	8.66 ± 0.40 (Tshaj tawm)
Kev cia khoom	2-8 ° C
Refractive Index	1.67 ib

Product Detail

LogP	0.9 ntawm pH 6.6
siv	4-[(4-hydroxy-2-pyrimidinyl) amino] benzonitrile tuaj yeem siv los ua ib qho nruab nrab ntawm cov organic synthesis thiab cov kws tshuaj nruab nrab, thiab tuaj yeem siv rau hauv chav kuaj Organic synthesis txheej txheem thiab tshuaj thiab tshuaj tshawb fawb thiab kev loj hlob.
kev npaj	hnyav 2-(methylthio) pyrimidine -4(3H)-ib (3g,21mmol) thiab 4-aminobenzonitrile (2.99g,25mmol) nyob rau hauv 50mL puag ncig hauv qab khob, tiv thaiv los ntawm nitrogen, maj mam rhuab mus rau 180 ℃, thiab reacted rau 8 teev. Tom qab cov tshuaj tiv thaiv txias, 20mL ntawm acetonitrile yog ntxiv rau kev kho ultrasonic, pom, lim ncuav mog qab zib yog ntxuav nrog acetonitrile, tsis muaj 4-aminobenzonitrile residue yog kuaj los ntawm TLC, thiab lub teeb daj khoom tau los ntawm ziab lub ncuav mog qab zib lim yog 4-( (4-oxo -1, 6-dihydropyrimidine -2-yl) amino) benzonitrile nrog a yield ntawm 73.6%.