5-Bromo-3-nitro-2-pyridinol (CAS # 15862-34-7)
Risk thiab Safety
| Risk Codes | R22 - Ua phem yog tias nqos R37/38 - Kab mob ua pa thiab tawv nqaij. R41 - Riam phom loj rau qhov muag R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij. R20 - Ua phem los ntawm kev nqus pa |
| Kev nyab xeeb piav qhia | S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob. S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag. S36 - Hnav khaub ncaws tiv thaiv zoo. |
| UN IDs | 2811 ib |
| WGK Germany | 3 |
| HS Code | 29337900 ib |
| Kev Ceeb Toom | Ua phem |
| Hazard Class | IRRITANT |
Cov ntaub ntawv siv
| Siv | 5-bromo-2-hydroxy-3-nitropyridine yog cov organic nruab nrab uas siv tau los npaj cov tebchaw 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl) ]-4-yl) ethyl)-5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H)-ib, cov tshuaj no yog DOCK1 inhibitory compound. |
| txheej txheem synthesis | nitric acid (60-61%, 3.5mL) tau ntxiv rau cov tshuaj (10mL) ntawm 5-bromopyridine -2(1H)-ib qho (1.75g,10.1mmol) hauv sulfuric acid ntawm 0 ℃. Qhov sib tov yog tso cai kom sov rau chav tsev kub thiab nplawm rau 3 teev. Cov tshuaj tiv thaiv sib tov yog nchuav rau hauv dej khov dej thiab cov dej nag uas tshwm sim yog sau los ntawm kev pom. Cov khoom tsim tau raug ntxuav nrog dej thiab qhuav hauv lub tshuab nqus tsev, muab 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% tawm los) ua cov khoom dawb. 1 H NMR(500MHz,CDCl3)δ:8.57(s,1H), 8.26(s,1H). |
Sau koj cov lus ntawm no thiab xa tuaj rau peb
