5-Fluorocytosine (CAS # 2022-85-7)
Risk thiab Safety
| Risk Codes | R40 - Cov pov thawj txwv ntawm cov nyhuv carcinogenic R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij. R63 - Muaj peev xwm tsim kev puas tsuaj rau tus menyuam hauv plab |
| Kev nyab xeeb piav qhia | S22 - Tsis txhob nqus plua plav. S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg ua tau.) S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog. S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag. S27 - Tshem tawm tag nrho cov khaub ncaws tsis huv tam sim ntawd. S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob. |
| WGK Germany | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F CODE | 10-23 |
| HS Code | 293359 0 |
| Kev Ceeb Toom | Toxic/light Sensitive |
| Hazard Class | IRRITANT, LIGHT SENS |
| Toxicity | LD50 hauv nas (mg / kg): > 2000 qhov ncauj thiab sc; 1 190;ib. 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS # 2022-85-7) Taw qhia
zoo
Cov khoom no yog cov hmoov dawb los yog dawb crystalline hmoov, tsis muaj ntxhiab los yog tsw ntxhiab me ntsis. me ntsis soluble hauv dej, solubility ntawm 1.2% ntawm 20 ° C hauv dej, me ntsis soluble hauv ethanol; Nws yuav luag insoluble hauv chloroform thiab ether; Soluble nyob rau hauv dilute hydrochloric acid los yog dilute sodium hydroxide tov. Nws ruaj khov ntawm chav tsev kub, precipitates crystals thaum txias, thiab ib feem me me hloov mus rau hauv 5-fluorouracil thaum rhuab.
Cov khoom no yog cov tshuaj tua kab mob uas tau tsim tawm hauv xyoo 1957 thiab siv hauv kev kho mob hauv xyoo 1969, nrog rau cov nyhuv antibacterial pom tseeb ntawm Candida, cryptococcus, colouring fungi thiab Aspergillus, thiab tsis muaj kev cuam tshuam rau lwm cov fungi.
Nws cov nyhuv inhibitory ntawm fungi yog vim nws nkag mus rau hauv cov hlwb ntawm cov kab mob rhiab heev, qhov twg nyob rau hauv qhov kev txiav txim ntawm nucleopyine deaminase, tshem tawm cov amino pawg los tsim cov antimetabolite-5-fluorouracil. Cov tom kawg yog hloov mus rau 5-fluorouracil deoxynucleoside thiab inhibits thymine nucleoside synthetase, thaiv kev hloov pauv ntawm uracil deoxynucleoside rau hauv thymine nucleoside, thiab cuam tshuam rau DNA synthesis.
siv
Antifungals. Nws yog tsuas yog siv rau mucocutaneous candidiasis, candidal endocarditis, candidal mob caj dab, cryptococcal meningitis thiab chromomycosis.
Kev siv thiab ntau npaum ntawm qhov ncauj, 4 ~ 6g ib hnub, muab faib ua 4 zaug.
kev ruaj ntseg
Cov ntshav suav yuav tsum tau kuaj xyuas tsis tu ncua thaum lub sijhawm tswj hwm. Cov neeg mob uas muaj lub siab thiab lub raum tsis txaus thiab cov kab mob ntshav thiab cov poj niam cev xeeb tub yuav tsum siv ceev faj; Contraindicated nyob rau hauv cov neeg mob uas mob raum tsis ua hauj lwm.
Shading, airtight cia.
