5-Fluorouracil (CAS # 51-21-8)

Chemical Property:

Molecular Formula	C4H3FN2O2
Molar Mass	130.08 Nws
Qhov ntom	1.4593 (kwv yees)
Melting Point	282-286 ° C (Lub Kaum Ob Hlis) (lit.)
Boling Point	190-200 ° C / 0.1mmHg
Dej Solubility	12.2 g / L 20 ºC
Solubility	Me ntsis soluble hauv ethanol. Nws yuav luag insoluble hauv chloroform thiab yaj hauv sodium hydroxide tov.
Qhov tshwm sim	Dawb los yog dawb zoo li crystalline hmoov
Xim	dawb
Merck	14, 4181 ib
BRN	127172 ib
pKa	pKa 8.0 ± 0.1 (H2O) (tsis paub); 3.0 ± 0.1 (H2O) (Tsis paub)
PH	4.3-5.3 (10g / l, H2O, 20 ℃)
Kev cia khoom	2-8 ° C
Kev ruaj ntseg	ruaj khov. Lub teeb rhiab heev. Hluav taws kub. Incompatible nrog muaj zog oxidizing neeg sawv cev, muaj zog hauv paus.
rhiab heev	Huab cua Sensitive
Refractive Index	1.542 ib
MDL	PAB 00006018
Physical thiab Chemical Properties	melting point 282-286 ° C (dec.) (lit.) khaws cia rau ntawm 0-5 solubility H2O: 10 mg/mL, ntshiab daim ntawv hmoov xim dawb dej solubility 12.2g / L 20 oC Huab cua Sensitive ib 14,4181 TIAB SA 127172
Siv	Rau digestive system mob cancer, mob taub hau thiab caj dab, mob qog noj ntshav gynecological, mob ntsws cancer, mob qog noj ntshav, mob qog noj ntshav thiab kho mob qog noj ntshav.

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Khoom cim npe

Risk Codes	R22 - Ua phem yog tias nqos R20/21/22 - Ua phem los ntawm kev nqus pa, tiv thaiv daim tawv nqaij thiab yog tias nqos. R52 - Ua phem rau cov kab mob hauv dej R25 - Toxic yog nqos
Kev nyab xeeb piav qhia	S36 - Hnav khaub ncaws tiv thaiv zoo. S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog. S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag. S22 - Tsis txhob nqus plua plav. S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg ua tau.) S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	YR0350000
FLUKA BRAND F CODE	10-23
TSCA	T
HS Code	2933595 ib
Kev Ceeb Toom	Irritant/Highly Toxic
Hazard Class	6.1
Packing Group	III
Toxicity	LD50 qhov ncauj hauv Luav: 230 mg / kg

Taw qhia

Cov khoom no yog thawj zaug hloov mus rau 5-fluoro-2-deoxyuracil nucleotides hauv lub cev, uas inhibits thymine nucleotide synthase thiab thaiv kev hloov pauv ntawm deoxyuracil nucleotides rau hauv deoxythymine nucleotides, yog li inhibiting DNA biosynthesis. Tsis tas li ntawd, los ntawm kev tiv thaiv kev koom ua ke ntawm uracil thiab rotic acid rau hauv RNA, cov nyhuv ntawm inhibiting RNA synthesis tiav. Cov khoom no yog ib lub voj voog ntawm cov tshuaj tshwj xeeb, feem ntau inhibiting S theem hlwb.

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Tom ntej: 2-HYDROXY-3-AMINO-5-PICOLINE (CAS # 52334-51-7)

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