ALPHA-ISO-METHYLIONONE CAS Nr 127-51-5
| Hazard Cov Cim | Xi-xaj |
| Risk Codes | 43 - Tej zaum yuav ua rau mob ntawm daim tawv nqaij |
| Kev nyab xeeb piav qhia | S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog. |
| UN IDs | UN1230 - chav kawm 3 - PG 2 - Methanol, daws |
| WGK Germany | 2 |
| Toxicity | GRAS (FEMA). |
Taw qhia
qhia
Kev sib xyaw ntawm methyl thiab ethyl isomethyl violet ketone thiab methyl thiab ethyl ortho methyl violet ketone.
xwm
Alpha isomethylprednisolone yog ib qho organic compound. Nws yog xim liab crystalline khoom. Nyob rau hauv chav tsev kub, nws muaj ib tug tshwj xeeb aromatic tsw.
Alpha isomethylprednisolone yog ib qho tshuaj tsw qab ketone. Nws tau txais los ntawm cov tshuaj tiv thaiv methylation ntawm violet cawv thiab hu ua isomethyl violet ketone. Nws cov qauv molecular muaj lub nplhaib uas muaj ntxhiab thiab ib pawg ketone.
Nyob rau hauv chav tsev kub, nws yog khoom, tab sis nws yuav yaj los ntawm cua sov. Nws yog insoluble hauv dej, tab sis tuaj yeem yaj hauv qee cov kuab tshuaj organic xws li ethanol thiab dichloromethane. Nws yog rhiab heev rau lub teeb thiab tuaj yeem raug photolysis cov tshuaj tiv thaiv nyob rau hauv ultraviolet lub teeb irradiation.
Hais txog cov khoom siv tshuaj, α - isomethylprednisolone yog ib qho tshuaj tiv thaiv. Nws tuaj yeem ua rau muaj kev cuam tshuam xws li oxidation, txo qis, ntxiv, thiab hloov pauv. Nws reacts nrog ib co electrophilic reagents los tsim cov khoom ntxiv. Nws tuaj yeem raug protonated nyob rau hauv lub xub ntiag ntawm muaj zog acids. Nws kuj tseem tuaj yeem hloov mus rau hauv ketone acids los ntawm cov tshuaj tiv thaiv oxidation.
Txoj kev tsim khoom
Hauv qab no yog ib txoj hauv kev los tsim alpha isomethylprednisolone:
Kev npaj cov khoom pib: Npaj cov ntaub ntawv thawj zaug, suav nrog Isobutyl ketone thiab Cyclohexanone. Ob lub tebchaw no yog qhov tseem ceeb ua ntej rau kev sib txuas ntawm α - isomethylprednisolone.
Kev teeb tsa cov tshuaj tiv thaiv: Reacte isodecanone thiab cyclohexanol raws li qhov tsim nyog. Ib qho xwm txheej tshwm sim yog ua cov tshuaj tiv thaiv nyob rau hauv acidic tej yam kev mob, thiab feem ntau siv cov kua qaub catalysts xws li sulfuric acid (H2SO4) thiab phosphoric acid (H3PO4).
Cov kauj ruam tshuaj tiv thaiv: Sib tov ib qho nyiaj ntawm isodecanone thiab cyclohexanol, thiab ntxiv cov kua qaub catalyst. Tom qab ntawd, cov tshuaj tiv thaiv yog nqa tawm ntawm qhov ntsuas kub uas tsim nyog, nrog rau qhov kub thiab txias ntawm 50-70 degrees Celsius. Lub sijhawm tshuaj tiv thaiv feem ntau yog ob peb teev mus rau kaum teev.
Kev sib cais thiab purification: Tom qab cov tshuaj tiv thaiv tiav, cov khoom yog purified los ntawm cov tshuaj tiv thaiv sib tov los ntawm distillation los yog lwm yam kev sib cais.
Crystallization thiab ziab: Crystallize thiab qhuav cov khoom purified kom tau txais qhov kawg alpha isomethylprednisolone khoom.
