Dabigatran etexilate (CAS # 211915-06-9)

Chemical Property:

Molecular Formula	C34H41N7O5
Molar Mass	627.73 ib
Qhov ntom	1.24 ± 0.1 g / cm3 (Tshaj tawm)
Melting Point	128-129 °
Boling Point	827.9 ° C ntawm 760 mmHg
Flash Point	454.5°C dej
Solubility	DMSO (me ntsis), Methanol (me ntsis)
Vapor Siab	1.49E-27mmHg ntawm 25 ° C
Qhov tshwm sim	Khoom
Xim	Dawb rau daj daj
pKa	9.88 ± 0.46 (Tshaj tawm)
Kev cia khoom	Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C
Kev ruaj ntseg	Hygroscopic
Refractive Index	1.614 ib
Kev tshawb nrhiav hauv vitro	Dabigatran xaiv thiab thim rov qab inhibits tib neeg thrombin (Ki: 4.5 nM) thiab thrombin-induced platelet aggregation (IC50: 10 nM) thiab tsis muaj kev cuam tshuam rau lwm cov platelet stimulating agents. Dabigatran inhibits tiam ntawm (PPP) thrombin nyob rau hauv lub plasma ntawm depleted platelets nrog IC50 ntawm 0.56 μm raws li ntsuas los ntawm endogenous thrombin Index (ETP). Hauv kev sim hauv vitro, Dabigatran muaj qhov concentration-dependent anticoagulant nyhuv ntawm ntau hom. Hauv tib neeg PPP, lub sijhawm ua haujlwm ib nrab thromboplastin (aPTT), lub sijhawm prothrombin (PT) tau nce ob npaug ntawm qhov siab ntawm 0.23,0.83 thiab 0.18 μm, feem. Thiab Ecarin clotting lub sij hawm (ECT).
Hauv vivo kawm	Dabigatran dose-dependently prolonged aPPT tom qab txhaj tshuaj rau cov nas (0.3,1 thiab 3 mg / kg) thiab rhesus liab (0.15,0.3 thiab 0.6 mg / kg). Dabigatran etexilate (20 mg / kg, PO) ua rau lub sijhawm ntev ntawm tus nqi k thiab tsawg dua attenuation ntawm qhov siab tshaj plaws nce hauv npua tshaj enoxaparin. Dabigatran (0.01-0.1 mg / kg) koob tshuaj-raws li txo cov thrombosis, nrog ED50 (50% koob tshuaj zoo) yog 0.033 mg / kg thiab ua tiav inhibition ntawm 0.1 mg / kg. Dabigatran etexilate (5-30 mg / kg) inhibited thrombus tsim nyob rau hauv ib koob-thiab-lub sij hawm-nyob ntawm tus yam ntxwv, nrog rau qhov siab tshaj plaws inhibition tshwm sim tom qab 30 min ntawm pretreatment, qhia tau hais tias cov nyhuv sai.

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Product Detail

Khoom cim npe

Taw qhia

Dibutyl phthalate yog ib qho organic compound. Nws yog ib qho xim tsis muaj xim rau lub teeb daj ua kua nrog cov tshuaj tsw qab tshwj xeeb.

Dabigatran etexilate feem ntau yog siv los ua plasticizer. Nws tuaj yeem txhim kho qhov softness thiab ductility ntawm cov yas, yog li nws yog dav siv nyob rau hauv kev tsim cov khoom yas, xws li yas zaj duab xis, yas kav, yas flooring thiab khau yas. Nws kuj tseem siv tau los ua ib qho ntxiv rau cov kuab tshuaj, cov roj nplua nyeem thiab cov tshuaj tsw qab.

Dabigatran etexilate feem ntau yog npaj los ntawm esterification ntawm phthalic anhydride nrog n-butanol lossis isobutanol. Cov tshuaj tiv thaiv feem ntau yog ua nyob rau hauv lub xub ntiag ntawm ib tug acid catalyst ntawm qhov tsim nyog kub thiab siab.

Nws tuaj yeem ua rau tawv nqaij thiab qhov muag thiab yuav tsum tau yaug nrog dej ntau tam sim ntawd tom qab sib cuag. Tsis txhob hnov qab txog cov oxidants, zam cov khoom siv hluav taws xob thiab kom deb ntawm qhov kub thiab txias thiab qhib nplaim taws thaum ua haujlwm thiab khaws cia. Nws yuav tsum tau zoo ventilated thaum siv kom tsis txhob vapor tsub kom.

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