Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate (CAS # 503615-07-4) )

Taw qhia

Cov hauv qab no yog kev qhia txog cov khoom, kev siv, kev npaj thiab cov ntaub ntawv kev nyab xeeb ntawm apixaban intermediate 3:

Zoo:

Apixaban intermediate 3 yog ib qho organic compound. Nws yog cov khoom thiab soluble hauv cov kuab tshuaj organic xws li ether thiab ethyl acetate.

Kev Siv: Nws yog feem ntau siv rau kev phais tshuaj loog thiab kho mob hnyav.

Txoj kev:

Txoj kev npaj ntawm apixaban intermediate 3 tuaj yeem ua tiav los ntawm cov kauj ruam hauv qab no: p-nitrobenzoic acid yog reacted nrog hypobutylthiourea nyob rau hauv kev sib koom ntawm acetic acid thiab thionyl chloride kom tau N-(p-nitrophenyl)-N-(hypobutylthioylurea) formic acid, thiab ces, reacted nrog sodium hydroxide nyob rau hauv sodium oxide thiab methanol tov kom tau apixaban nruab nrab 3.

Cov Ntaub Ntawv Kev Nyab Xeeb: Cov txheej txheem kev nyab xeeb nruj yuav tsum tau ua raws thaum siv thiab tuav cov khoom sib xyaw no. Kev sib cuag ncaj qha lossis nqus pa tuaj yeem ua rau muaj mob hnyav rau tib neeg kev noj qab haus huv. Nws cov ntaub ntawv kev nyab xeeb tshwj xeeb yuav tsum raug soj ntsuam thiab ua tiav raws li cov cai thiab cov txheej txheem tsim nyog los xyuas kom meej tias kev siv thiab tuav tau zoo. Thaum ua cov kev sim tshuaj synthesis, lawv yuav tsum tau ua nyob rau hauv qhov chaw kuaj mob tsim nyog thiab cov cuab yeej tiv thaiv tus kheej xws li tsom iav tshuaj, cov hnab looj tes tiv thaiv, thiab cov khaub ncaws tiv thaiv yuav tsum tau siv.