FMOC-Arg(Pbf)-OH (CAS # 154445-77-9)
Risk thiab Safety
| Hazard Cov Cim | Xi-xaj |
| Risk Codes | 36/37/38 – Khaus qhov muag, ua pa thiab tawv nqaij. |
| Kev nyab xeeb piav qhia | S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob. S36 - Hnav khaub ncaws tiv thaiv zoo. |
| WGK Germany | 1 |
| HS Code | 2935 90 90 ib |
| Hazard Class | IRRITANT |
Taw qhia
FMOC-protecting pab pawg yog ib feem siv cov amino acid tiv thaiv pab pawg uas tiv thaiv cov amino functional pawg ntawm arginine. Cov hauv qab no yog kev qhia txog qee yam ntawm cov khoom, kev siv, kev npaj, thiab cov ntaub ntawv kev nyab xeeb ntawm Fmoc-Protective Radical:
Zoo:
FMOC-tiv thaiv pab pawg yog pab pawg tiv thaiv tshem tau uas tiv thaiv cov amino amino pawg. Nws tuaj yeem cuam tshuam nrog pawg amino hauv arginine los ntawm esterification cov tshuaj tiv thaiv los ua Fmoc-arginine ester, thiaj li ua tiav lub hom phiaj ntawm kev tiv thaiv cov amino pawg. Muaj cov pab pawg muaj ntxhiab ntawm Fmoc-tiv thaiv pab pawg molecule uas muaj zog nqus UV lub teeb, uas tso cai rau kev tshem tawm ntawm Fmoc-tiv thaiv pab pawg ua los ntawm UV irradiation lossis tshuaj siv tshuaj.
Siv:
FMOC-tiv thaiv pab pawg tau dav siv hauv peptide synthesis thiab solid-phase synthesis. Nws tuaj yeem tiv thaiv arginine amino pawg kom tiv thaiv nws cov kev tawm tsam sab nraud thaum lub sijhawm sib txuas. Hauv peptide synthesis, Fmoc-tiv thaiv pab pawg tuaj yeem raug tshem tawm los ntawm cov kab mob alkaline, tso cai rau kev sib txuas ntawm polypeptides mus ntxiv.
Txoj kev:
Fmoc-tiv thaiv pab pawg tuaj yeem npaj tau los ntawm cov tshuaj tiv thaiv ntawm Fmoc-Cl thiab arginine. Fmoc-Cl yog ib qho acidic reagent reacts nrog cov amino pawg hauv arginine los ua Fmoc-arginine ester. Cov tshuaj tiv thaiv feem ntau yog nqa tawm hauv ethanol ntawm chav tsev kub rau dej khov dej kub.
Cov ntaub ntawv kev nyab xeeb:
FMOC-Protective Radicals muaj kev nyab xeeb siv nyob rau hauv ib qho chaw kuaj mob, tab sis cov hauv qab no yuav tsum tau sau tseg:
- FMOC-CL yog ib qho ua rau khaus thiab muaj kuab lom, yuav tsum tau saib xyuas kom tsis txhob muaj kev sib cuag nrog daim tawv nqaij, nqus tau lossis nqus tau. Ua haujlwm nyob rau hauv qhov chaw uas muaj cua zoo thiab hnav cov khoom tiv thaiv tus kheej tsim nyog.
- FMOC-Protective Base muaj cov khoom muaj zog nqus ntawm ultraviolet rays, yog li yuav tsum tau saib xyuas kom tsis txhob muaj kev sib cuag ncaj qha nrog daim tawv nqaij thiab qhov muag thaum siv, thiab kom deb ntawm lub teeb muaj zog.
- Muaj zog acid hydrolysis tiv thaiv xws li pentafluorophenylcarboxylic acid (TFA) feem ntau yog siv thaum lub sij hawm tshem tawm ntawm Fmoc-protective pab pawg neeg, thiab nws yuav tsum tau nco ntsoov hais tias cov vapor ntawm TFA tej zaum yuav ua rau kev puas tsuaj, yog li ntawd nws yog tsim nyog los ua hauj lwm nyob rau hauv lub qhov dej. thaj chaw ventilated.
