fmoc-O-tert-butyl-D-tyrosine (CAS # 118488-18-9)
Fmoc-O-tert-butyl-D-tyrosine yog ib qho tshuaj tiv thaiv amino acid uas nquag siv. Cov hauv qab no yog cov lus piav qhia ntawm nws qhov xwm txheej, kev siv, kev tsim thiab cov ntaub ntawv kev nyab xeeb:
Xwm:
Fmoc-O-tert-butyl-D-tyrosine yog dawb crystalline khoom. Nws yog cov organic compound nrog cov tshuaj formula C30H31NO7 thiab molecular hnyav ntawm 521.57g / mol. Lub compound yog ib tug derivative ntawm tyrosine nyob rau hauv uas cov amino pawg bears Fmoc (9-fluorofluorenylformyl) pab pawg neeg tiv thaiv thiab cov carboxylic acid pawg yog esterified nrog O-tert-butyl.
Siv:
Fmoc-O-tert-butyl-D-tyrosine feem ntau yog siv los tiv thaiv cov amino acid hauv peptide synthesis. Los ntawm kev txuas Fmoc tiv thaiv pab pawg rau cov amino pawg, cov kev xav sab nraud tuaj yeem tiv thaiv thaum lub sijhawm sib txuas. Nws yog dav siv nyob rau hauv cov khoom theem synthesis thiab tuaj yeem siv los ua ke polypeptides thiab cov proteins.
Txoj Kev Npaj:
Kev npaj ntawm Fmoc-O-tert-butyl-D-tyrosine feem ntau yog ua los ntawm cov tshuaj synthesis. Ua ntej, tyrosine reacted nrog Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) los tsim Fmoc-O-tyrosine. Cesium tert-butyl bromide yog ntxiv rau cov tshuaj tiv thaiv esterify pawg carboxylic acid los ua Fmoc-O-tert-butyl-D-tyrosine. Thaum kawg, cov khoom ntshiab yog tau los ntawm cov kauj ruam ntawm crystallization, ntxuav thiab ziab.
Cov ntaub ntawv kev nyab xeeb:
Fmoc-O-tert-butyl-D-tyrosine yog ib qho chaw ruaj khov nyob rau hauv cov xwm txheej ib txwm muaj thiab tsis muaj qhov pom tseeb volatilization ntawm chav tsev kub. Thaum siv, nws yog ib qho tsim nyog yuav tsum ua raws li cov txheej txheem kev nyab xeeb hauv chav kuaj, hnav cov cuab yeej tiv thaiv tsim nyog, thiab tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag. Thaum tuav los yog khaws cia, nws yuav tsum tau khaws cia rau hauv qhov chaw qhuav, txias thiab deb ntawm hluav taws thiab oxidizing cov neeg ua haujlwm. Nyob rau tib lub sijhawm, kev sib cuag nrog cov oxidants muaj zog thiab muaj zog acids yuav tsum tau zam kom tsis txhob muaj kev phom sij txaus ntshai. Nrhiav kev pab kho mob tam sim yog tias noj los yog raug mob rau qhov sib xyaw.
