Tom ntej: Fmoc-L-4-hydroxyproline CAS # 88050-17-3

Taw qhia

Fmoc-L-hydroxyproline (Fmoc-Hyp-OH) yog ib qho amino acid derivative nrog cov khoom hauv qab no thiab siv:

Zoo:

- Pom: Dawb los yog dawb crystalline hmoov

- Solubility: Soluble nyob rau hauv organic solvents xws li DMF, DMSO thiab methanol

- pKa tus nqi: 2.76

Siv:

- Fmoc-Hyp-OH feem ntau yog siv rau peptide synthesis thiab peptide synthesis nyob rau hauv solid-phase synthesis

- Nws ua raws li ib feem ntawm pab pawg tiv thaiv los tiv thaiv sab saw ua haujlwm pab pawg ntawm cov amino acids thaum lub sij hawm sib zog-theem synthesis kom tsis txhob muaj kev xav tsis txaus ntseeg thiab tswj kev xaiv

Txoj kev:

Fmoc-Hyp-OH tuaj yeem npaj los ntawm reacting Fmoc-amino acids nrog L-hydroxyproline hauv cov kuab tshuaj haum. Cov kev mob tshwm sim feem ntau suav nrog qhov ntsuas kub thiab qhov tsim nyog catalyst, xws li N, N-dimethylpyrrolidone (DMAP). Cov khoom tsim tau raug ntxuav los ntawm cov kauj ruam xws li nag lossis daus, ntxuav, thiab ziab.

Cov ntaub ntawv kev nyab xeeb:

- FMOC-HYP-OH yog ib qho organic compound thiab yuav tsum tau ua raws li kev soj ntsuam kev nyab xeeb.

- Cov hmoov av tuaj yeem nqus tau thiab nkag mus rau ntawm daim tawv nqaij, yog li yuav tsum tau saib xyuas kom tsis txhob nqus ncaj qha lossis tiv tauj.

- Thaum lub sijhawm ua haujlwm, cov khoom siv tiv thaiv tus kheej tsim nyog xws li cov hnab looj tes hauv chav kuaj, tiv thaiv qhov muag, hnav khaub ncaws tiv thaiv, thiab lwm yam.

- Nws yuav tsum tau muab kaw nruj nreem kaw rau hauv qhov chaw qhuav, txias, kom deb ntawm cov hluav taws kub thiab hluav taws kub.