L-Pyroglutamic acid CAS 98-79-3
Risk thiab Safety
| Hazard Cov Cim | Xi-xaj |
| Risk Codes | 36/37/38 – Khaus qhov muag, ua pa thiab tawv nqaij. |
| Kev nyab xeeb piav qhia | S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob. S36 - Hnav khaub ncaws tiv thaiv zoo. S37/39 - Hnav cov hnab looj tes tsim nyog thiab tiv thaiv qhov muag / ntsej muag |
| WGK Germany | 3 |
| RTECS | TW 3710 000 |
| FLUKA BRAND F CODE | 21 |
| TSCA | Yog lawm |
| HS Code | 29337900 ib |
| Taw qhia | pyroglutamic acid yog 5-oxyproline. Nws yog tsim los ntawm lub cev qhuav dej ntawm α-NH2 pawg thiab γ-hydroxyl pawg ntawm glutamic acid los tsim ib daim ntawv cog lus molecular lactam; Nws kuj tuaj yeem tsim los ntawm kev poob ib pawg Amido hauv glutamine molecule. Yog tias glutathione synthetase tsis txaus, tuaj yeem ua rau pyroglutamemia, cov tsos mob tshwm sim. Pyroglutamemia yog ib qho teeb meem ntawm cov organic acid metabolism los ntawm glutathione synthetase deficiency. Kev kho mob tshwm sim ntawm kev yug me nyuam 12 ~ 24 teev ntawm qhov pib, nce hemolysis, jaundice, mob metabolic Acidosis, mob hlwb, thiab lwm yam .; Cov zis muaj pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Kev kho mob, cov tsos mob, xyuam xim kho cov khoom noj tom qab hnub nyoog. |
| khoom | L-pyroglutamic acid, tseem hu ua L-pyroglutamic acid, L-pyroglutamic acid. Los ntawm ethanol thiab roj av ether sib tov nyob rau hauv cov nag lossis daus ntawm cov xim tsis muaj xim orthorhombic ob lub khob hliav qab Crystal, melting point ntawm 162 ~ 163 ℃. Soluble hauv dej, cawv, acetone thiab acetic acid, ethyl acetate-soluble, insoluble hauv ether. Kev sib hloov kho qhov muag tshwj xeeb -11.9 ° (c = 2,H2O). |
| Nta thiab siv | Nyob rau hauv tib neeg daim tawv nqaij muaj ib tug moisturizing muaj nuj nqi ntawm dej-soluble tshuaj-natural moisturizing yam, nws muaj pes tsawg leeg yog roughly amino acid (muaj 40%), pyroglutamic acid (muaj 12%), inorganic ntsev (Na, K, Ca, Mg, thiab lwm yam. muaj 18.5%), thiab lwm yam organic compounds (muaj 29.5%). Yog li, pyroglutamic acid yog ib qho ntawm cov khoom tseem ceeb ntawm cov tawv nqaij ntuj moisturizing, thiab nws muaj peev xwm moisturizing deb tshaj li ntawm glycerol thiab propylene glycol. Thiab tsis muaj tshuaj lom, tsis muaj stimulation, yog ib qho kev kho tawv nqaij niaj hnub, Kev kho plaub hau tshuaj pleev ib ce zoo heev raw cov ntaub ntawv. Pyroglutamic acid kuj tseem muaj kev cuam tshuam rau kev ua haujlwm ntawm tyrosine oxidase, yog li tiv thaiv cov khoom "melanoid" hauv daim tawv nqaij, uas muaj cov nyhuv whitening ntawm daim tawv nqaij. Nws muaj cov nyhuv softening ntawm daim tawv nqaij, tuaj yeem siv rau cov tshuaj pleev ib ce. Ntxiv rau daim ntawv thov hauv cov tshuaj pleev ib ce, L-pyroglutamic acid kuj tuaj yeem tsim cov derivatives nrog rau lwm cov organic compounds, uas muaj cov teebmeem tshwj xeeb ntawm kev ua haujlwm saum npoo av, pob tshab thiab ci ntsa iab, thiab lwm yam. Nws kuj tseem tuaj yeem siv los ua cov tshuaj tua kab mob rau cov tshuaj detergents; Tshuaj reagents rau kev daws teeb meem ntawm racemic amines; Organic intermediates. |
| txoj kev npaj | L-pyroglutamic acid yog tsim los ntawm kev tshem tawm ib feeb ntawm cov dej los ntawm cov molecule ntawm L-glutamic acid, thiab nws cov txheej txheem kev npaj yog yooj yim, cov kauj ruam tseem ceeb yog kev tswj ntawm kub thiab dewatering lub sij hawm. (1) 500g ntawm L-glutamic acid tau ntxiv rau 100 ml beaker, thiab lub beaker tau rhaub nrog roj da dej, thiab qhov kub thiab txias tau nce mus rau 145 txog 150 ° C, thiab qhov kub thiab txias tau khaws cia rau 45 feeb kom lub cev qhuav dej. tshuaj tiv thaiv. Lub cev qhuav dej yog Tan. (2) Tom qab ua tiav cov tshuaj tiv thaiv lub cev qhuav dej, cov tshuaj tau muab nchuav rau hauv cov dej kub npau npau li 350, thiab cov tshuaj tau yaj tag nrho hauv dej. Tom qab txias rau 40 txog 50 ° C., qhov tsim nyog ntawm cov pa roj carbon activated tau ntxiv rau decoloration (rov ua ob zaug). Tau txais ib qho kev daws teeb meem uas tsis muaj xim pob tshab. (3) Thaum cov xim tsis muaj xim pob tshab npaj rau hauv kauj ruam (2) ncaj qha rhuab thiab evaporated kom txo qhov ntim mus txog ib nrab, tig mus rau hauv dej da dej thiab txuas ntxiv mus rau qhov ntim ntawm li 1/3, koj tuaj yeem nres cua sov, thiab hauv cov dej kub da dej kom qeeb cov crystallization, 10 mus rau 20 teev tom qab kev npaj cov xim tsis muaj xim prismatic. Tus nqi ntawm L-pyroglutamic acid nyob rau hauv cov tshuaj pleev ib ce nyob ntawm tus qauv. Cov khoom no kuj tseem siv tau rau cov tshuaj pleev ib ce hauv daim ntawv ntawm 50% kev daws teeb meem. |
| glutamic acid | glutamic acid yog ib qho amino acid tsim cov protein, muaj ionized acidic sab saw, thiab nthuav tawm hydrotropism. Glutamic acid yog raug rau cyclization rau hauv pyrrolidone carboxylic acid, i.e., pyroglutamic acid. glutamic acid yog tshwj xeeb tshaj yog nyob rau hauv tag nrho cov cereal proteins, muab alpha-ketoglutarate los ntawm lub tricarboxylic acid voj voog. Alpha ketoglutaric acid tuaj yeem ua ncaj qha los ntawm ammonia nyob rau hauv catalysis ntawm glutamate dehydrogenase thiab NADPH (coenzyme II), thiab tseem tuaj yeem catalyzed los ntawm aspartate aminotransferase los yog alanine aminotransferase, glutamic acid yog tsim los ntawm transamination ntawm aspartic acid los yog alanine; Tsis tas li ntawd, glutamic acid tuaj yeem hloov pauv nrog proline thiab ornithine (los ntawm arginine), feem. Yog li ntawd, Glutamate yog ib qho khoom noj khoom haus tsis tseem ceeb amino acid. Thaum glutamic acid deaminated nyob rau hauv lub catalysis ntawm glutamate dehydrogenase thiab NAD (coenzyme I) los yog kis tawm ntawm cov amino pawg nyob rau hauv lub catalysis ntawm aspartate aminotransferase los yog alanine aminotransferase los tsim alpha ketoglutarate, nws nkag mus rau lub tricarboxylic acid voj voog thiab generates suab thaj los ntawm lub gluconeogenic txoj kev, yog li glutamic acid yog ib qho tseem ceeb glycogenic amino acid. glutamic acid nyob rau hauv cov ntaub so ntswg sib txawv (xws li cov leeg, daim siab, lub hlwb, thiab lwm yam) tuaj yeem ua ke glutamine nrog NH3 los ntawm catalysis ntawm glutamine synthetase, nws yog cov khoom detoxification ntawm ammonia, tshwj xeeb tshaj yog nyob rau hauv cov ntaub so ntswg ntawm lub hlwb, thiab tseem khaws cia thiab siv daim ntawv. ammonia hauv lub cev (saib "glutamine thiab nws cov metabolism"). glutamic acid yog synthesized nrog acetyl-CoA raws li ib tug cofactor ntawm mitochondrial carbamoyl phosphate synthase (sib koom nyob rau hauv lub synthesis ntawm urea) los ntawm lub catalysis ntawm acetyl-glutamate synthase. γ-aminobutyric acid (GABA) yog ib yam khoom ntawm decarboxylation ntawm glutamic acid, tshwj xeeb tshaj yog nyob rau hauv high concentrations nyob rau hauv lub hlwb cov ntaub so ntswg, thiab kuj tshwm nyob rau hauv cov ntshav, nws physiological function yog suav tias yog inhibitory neurotransmitter, antispasmodic thiab hypnotic teebmeem exerted los ntawm lub Kev kho mob ntawm echinocandin tuaj yeem ua tiav los ntawm GABA. Lub catabolism ntawm GABA nkag mus rau lub voj voog tricarboxylic acid los ntawm kev hloov GABA transaminase thiab aldehyde dehydrogenase rau hauv succinic acid los tsim GABA shunt. |
| Siv | siv los ua intermediates hauv organic synthesis, zaub mov additives, thiab lwm yam. siv hauv cov khoom noj, tshuaj, tshuaj pleev ib ce thiab lwm yam lag luam |
Sau koj cov lus ntawm no thiab xa tuaj rau peb
