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Lacosamide CAS # 175481-36-4

Chemical Property:

Molecular Formula C13H18N2O3
Molar Mass 250.29 Nws
Qhov ntom 1.120 ± 0.06 g / cm3 (Tshaj tawm)
Melting Point 141-143; ib
Boling Point 536.4 ± 50.0 ° C (Predicted)
Kev sib hloov tshwj xeeb (α) D23 + 16.0 ° (c = 1 hauv CH3OH)
Flash Point 2 ℃
Vapor Siab 1.4E-11mmHg ntawm 25 ° C
pKa 14.19 ± 0.46 (Tshaj tawm)
Kev cia khoom Lub tub yees
Refractive Index 1.52 ib

Product Detail

Khoom cim npe

Risk thiab Safety

Risk Codes R11 - Cov nplaim hluav taws kub heev
R20/21/22 - Ua phem los ntawm kev nqus pa, tiv thaiv daim tawv nqaij thiab yog tias nqos.
R36 - Khau qhov muag
Kev nyab xeeb piav qhia S16 - Khaws kom deb ntawm qhov chaw hluav taws xob.
S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S36/37 - Hnav cov khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
UN IDs UN 1648 3 / PIB
WGK Germany 2
HS Code 2924296000

Lacosamide (CAS # 175481-36-4) Introduction

Lactamide yog ib chav kawm ntawm cov organic tebchaw uas muaj lactam rings. Cov hauv qab no yog kev qhia txog cov khoom, kev siv, kev npaj thiab cov ntaub ntawv kev nyab xeeb ntawm laclamide:

Zoo:
Cov khoom ntawm laclamide nyob ntawm nws cov qauv molecular thiab qhov loj ntawm lub nplhaib. Feem ntau, lacamide yog dawb crystalline khoom nrog ruaj khov. Nws muaj solubility zoo, soluble hauv cov kuab tshuaj organic xws li ethers thiab ketones, thiab insoluble hauv dej.

Siv:
Laccamide muaj ntau yam kev siv hauv kev lag luam tshuaj. Qhov tseem ceeb tshaj plaws ntawm cov no yog nws txoj kev siv ua ntej rau cov ntaub ntawv polymer. Piv txwv li, polyamide fibers (nylon) yog tsim los ntawm polymerizing laclamide. Laxamide tuaj yeem siv los ua ib qho nruab nrab hauv cov kuab tshuaj, catalysts, thiab ua cov khoom siv raw rau kev tsim cov fibers hluavtaws, hluavtaws roj hmab, tshuaj thiab dyes.

Txoj kev:
Feem ntau, cov synthesis ntawm laxamide yog ua tiav los ntawm acid-catalyzed cyclization. Tshwj xeeb, feem ntau siv cov txheej txheem npaj yog raws li hauv qab no:
Txoj kev pamine: siv amines thiab acid chloride los yog anhydride los ua raws li qhov tsim nyog los tsim laxamide.
Tsis yog-classical acid catalytic txoj kev: Piv txwv li, tom qab qhov nruab nrab hauv lub catalytic reactor tau kho tag nrho, ferric chloride thiab acid catalyst tuaj yeem hloov mus rau laclamide ntawm qhov kub thiab txias.
Txoj kev siv tshuaj tiv thaiv siab: Laclamine yog tsim los ntawm imimine ntaus ntawv thiab NBS nyob rau hauv ib puag ncig-siab.

Cov ntaub ntawv kev nyab xeeb:
Laxamide yog ib yam tshuaj thiab yuav tsum tau muab cia rau hauv qhov chaw qhuav, txias, kom deb ntawm qhov hluav taws kub thiab oxidants.
Thaum lub sijhawm ua haujlwm, qhov cua zoo yuav tsum tau khaws cia thiab cov cuab yeej tiv thaiv tus kheej tsim nyog xws li cov hnab looj tes tiv thaiv, daim npog ntsej muag, thiab cov looj tsom iav tiv thaiv yuav tsum tau siv.
Laclamide tuaj yeem ua rau tawv nqaij thiab qhov muag.
Thaum muab pov tseg, nws yuav tsum muab pov tseg kom tsim nyog raws li cov cai hauv zos.


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