Tom ntej: Methoxymethyl Triphenylphosphonium Chloride (CAS # 4009-98-7)

Siv

(Methoxymethyl) triphenylphosphorus chloride yog siv los ua ke cov cefaltacin, uas yog tshuaj tua kab mob thiab tshuaj tiv thaiv qog. Nws kuj yog siv los ua ib feem ntawm paclitaxel.

Kev npaj

Ib txoj hauv kev rau kev sib xyaw (methoxymethyl) triphenylphosphorus chloride, suav nrog cov kauj ruam hauv qab no: nyob rau hauv kev tiv thaiv ntawm nitrogen, ntxiv 50mL ntawm anhydrous acetone nyob rau hauv lub reactor, tom qab ntawd ntxiv 32g ntawm triphenylphosphine, nplawm thiab nce qhov kub ntawm 37 ° C, tswj qhov kub thiab txias. , ntxiv 20g ntawm methyl chloromethyl ether rau lub reactor, thiab tom qab ntawd reacting ntawm 37 ° C rau 3h, maj mam nce qhov kub mus rau 47 ° C ntawm tus nqi ntawm 1 ° C / min, cov tshuaj tiv thaiv txuas ntxiv rau 3h, cov tshuaj tiv thaiv tau nres, thiab 37.0g (methoxymethyl) triphenylphosphorus chloride. tau txais los ntawm kev pom, anhydric ether ntxuav thiab ziab nrog cov txiaj ntsig ntawm 88.5%.