Tom ntej: Methyl 2-cyanoisonicotinate CAS # 94413-64-6
Risk thiab Safety
| Hazard Class | 6.1 |
Txoj kev tsim khoom
lub hom phiaj compound tau npaj los ntawm oxidation, amidation thiab lub cev qhuav dej nrog methyl 2-methyl 4-pyridinecarboxylate (2) ua cov khoom pib. nws cov qauv tau lees paub los ntawm 1H NMR thiab MS, thiab tag nrho cov txiaj ntsig yog 53.0%. Cov teebmeem ntawm kev pub mis, crystallization kub, lub sij hawm tshuaj tiv thaiv thiab lwm yam ntawm cov khoom tau kawm los ntawm ib qho kev sim, thiab cov txheej txheem tau zoo: n(2): n (potassium permanganate) = 1.0: 2.5, crystallization kub 0 ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, cov tshuaj tiv thaiv; cov tshuaj tiv thaiv lub cev qhuav dej xaiv cov kab mob trifluoroacetic anhydride-triethylamine ua tus neeg ua haujlwm lub cev qhuav dej. Cov txheej txheem yog yooj yim rau kev khiav lag luam, cov tshuaj tiv thaiv tej yam kev mob yog me me, yooj yim rau scale li ntau lawm, thiab muaj zoo tswv yim daim ntawv thov nqi.
Siv
Tobisostat yog siv los kho mob hyperuricemia ntawm gout. Piv nrog rau cov tshuaj ib txwm siv allopurinol (purine analog), nws yuav tsis cuam tshuam rau purine thiab pyridine metabolism thiab enzyme kev ua haujlwm, thiab nws txo cov uric acid Cov nyhuv muaj zog dua, tsis tas yuav tsum tau siv tshuaj ntau dua, thiab kev nyab xeeb zoo dua. Methyl 2-cyano-4-pyridine carboxylate yog ib qho tseem ceeb raw khoom rau lub synthesis ntawm Tobiso.
