CAS Nr .: 53-19-0

Chemical Property:

Molecular Formula	C14H10Cl4
Molar Mass	320.04 Nws
Qhov ntom	1.3118 (kev kwv yees kwv yees)
Melting Point	77-78 ° C (lit.)
Boling Point	405.59 ° C (kev kwv yees kwv yees)
Dej Solubility	<0.1 g / 100 mL ntawm 24 ºC
Solubility	DMSO: soluble 20mg / ml, ntshiab
Qhov tshwm sim	hmoov
Xim	dawb rau beige
Merck	13,6237/13,6237
BRN	2056007 ib
Kev cia khoom	Inert cua, Chav Kub
Refractive Index	1.6000 (kwv yees)
Physical thiab Chemical Properties	Melting point 76-78 ° C dej-soluble <0.1g / 100 mL ntawm 24 ° C
Siv	Cov khoom no yog rau kev tshawb fawb tshawb fawb nkaus xwb thiab yuav tsum tsis txhob siv rau lwm lub hom phiaj.
Kev tshawb nrhiav hauv vitro	Hauv cov nas TalphaT1 cell kab, Mitotane inhibits qhov kev qhia thiab tso tawm ntawm TSH, thaiv cov lus teb ntawm TSH rau TRH, thiab txo cov cell viability, thiab induces apoptosis. Hauv pituitary TSH-secreting nas hlwb, Mitotane tsis cuam tshuam nrog cov thyroid hormones, tab sis ncaj qha txo qis secretory kev ua si thiab cell viability. Mitotane induces adrenal cortical necrosis, mitochondrial membrane puas, thiab irreversible khi rau cov protein CYP. Mitotane (10-40 μm) inhibited basal thiab cAMP-induced cortisol secretion tab sis tsis ua rau cell tuag. Mitotane tau pom cov teebmeem inhibitory ntawm basal StAR thiab P450scc proteins. Mitotane (40 μm) txo qis mRNA qib ntawm Star, CYP11A1 thiab cyp21. Mitotane (40 μm) yuav luag tag nrho neutralized induction ntawm STAR, CYP11A1, CYP17, thiab CYP21 mRNA los ntawm adenosine 8-bromo-cyclic phosphate. Nyob rau theem S ntawm H295R hlwb, kev sib xyaw ntawm Mitotane thiab gemcitabine pom kev tawm tsam thiab cuam tshuam nrog gemcitabine-mediated inhibition hauv lub voj voog ntawm tes.
Hauv vivo kawm	Hauv cov nas, Mitotane (60 mg / kg) txo qis adrenal mitochondrial thiab microsomal "P-450" thiab microsomal proteins los ntawm 34%, 55% thiab 35%.

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Khoom cim npe

Hazard Cov Cim	Xn – Ua phem
Risk Codes	40 - Cov pov thawj txwv ntawm cov nyhuv carcinogenic
Kev nyab xeeb piav qhia	36/37 - Hnav khaub ncaws tiv thaiv thiab hnab looj tes tsim nyog.
UN IDs	3249 ib
WGK Germany	3
RTECS	KH788000
HS Code	2903990002
Hazard Class	6.1 (b)
Packing Group	III

Taw qhia

Mitotane yog ib qho organic compound nrog cov tshuaj npe N, N'-methylene diphenylamine. Cov hauv qab no yog kev qhia txog cov khoom, kev siv, kev npaj thiab cov ntaub ntawv kev nyab xeeb ntawm mitotane:

Zoo:

- Mitotane yog cov xim tsis muaj xim crystalline uas yog soluble hauv cov kuab tshuaj organic xws li ethanol, ether, thiab chloroform.

- Mitotane muaj cov ntxhiab tsw muaj zog.

Siv:

- Mitotane feem ntau yog siv rau kev sib txuas cov tshuaj tiv thaiv hauv cov organic synthesis thiab feem ntau yog siv los ua reagent thiab catalyst.

- Nws tuaj yeem koom nrog ntau yam tshuaj lom neeg, xws li kev sib txuas ntawm alkynes, alkylation ntawm cov tshuaj tsw qab, thiab lwm yam.

Txoj kev:

- Mitotane tuaj yeem ua ke los ntawm cov tshuaj tiv thaiv ob-kauj ruam. Formaldehyde yog reacted nrog diphenylamine nyob rau hauv alkaline tej yam kev mob los tsim N-formaldehyde diphenylamine. Tom qab ntawd, los ntawm pyrolysis lossis tswj cov tshuaj tiv thaiv oxidation, nws hloov mus rau hauv mitotane.

Cov ntaub ntawv kev nyab xeeb:

- Mitotane yog ib qho ua kom khaus khaus thiab yuav tsum tsis txhob nkag mus rau ntawm daim tawv nqaij thiab qhov muag. Cov cuab yeej tiv thaiv tsim nyog xws li hnab looj tes, tsom iav, thiab khaub ncaws tiv thaiv yuav tsum hnav thaum ua haujlwm.

- Thaum khaws cia thiab tuav, ua tib zoo kaw thiab tiv thaiv lub teeb kom tsis txhob muaj huab cua thiab noo noo.

- Mitotane decomposes ntawm qhov kub siab los tsim cov pa roj carbon monoxide, tsis txhob cua sov lossis tiv tauj nrog lwm yam khoom siv hluav taws xob.

- Xa mus rau cov kev cai hauv zos thiab ua raws li cov txheej txheem kev nyab xeeb muaj feem xyuam thaum muab pov tseg.

Yav dhau los: 4-(4-methoxyphenyl)-1-butanol (CAS # 52244-70-9)

Tom ntej: 2-Chloro-5-aminopyridine (CAS # 5350-93-6)

Sau koj cov lus ntawm no thiab xa tuaj rau peb