N(alpha)-fmoc-N(epsilon)-(2-chloro-Z)-L-lysine (CAS # 133970-31-7)

Fmoc-(2-chlorobenzyloxycarbonyl) lysine yog ib qho kev siv cov amino acid derivative nrog cov khoom hauv qab no: 1. Qhov tsos: dawb crystalline hmoov;
2. molecular mis: C26H24ClNO5;
3. Molecular Luj: 459.92g/mol;
4. Solubility: Soluble nyob rau hauv organic solvents xws li dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, thiab lwm yam., insoluble nyob rau hauv dej;
5. Melting point: txog 170-175 ° C.Qhov kev siv ntawm Fmoc-(2-chlorobenzyloxycarbonyl) lysine yog raws li ib tug tiv thaiv thiab activating pab pawg neeg nyob rau hauv lub synthesis ntawm polypeptides. Nws pab pawg carboxyl tuaj yeem ua kom muaj zog los tsim cov ester, uas tom qab ntawd nkag mus rau cov tshuaj tiv thaiv condensation nrog cov amino acid residue los ua ke cov saw hlau polypeptide. Cov pab pawg Fmoc tuaj yeem raug tshem tawm yooj yim tom qab cov tshuaj tiv thaiv tiav kom nthuav tawm cov amino moiety tiv thaiv.

Txoj kev npaj Fmoc-(2-chlorobenzyloxycarbonyl) lysine feem ntau suav nrog cov kauj ruam hauv qab no:

1. reacting lysine nrog N-hydroxybutyrimide (Pbf) los qhia pab pawg tiv thaiv;
2. reacting lysine-Pbf derivative nrog 2-chlorobenzyl cawv los ua Fmoc-(2-chlorobenzyloxycarbonyl) lysine;
3. Cov khoom yog muab rho tawm nrog cov kuab tshuaj tsim nyog thiab purified los ntawm crystallization kom tau cov khoom ntshiab.

Hais txog cov ntaub ntawv kev nyab xeeb, Fmoc-(2-chlorobenzyloxycarbonyl) lysine yog cov tshuaj reagent thiab cov kev ntsuas kev nyab xeeb tsim nyog yuav tsum tau ua. Cov cuab yeej tiv thaiv tsim nyog, xws li hnab looj tes, tsom iav, thiab khaub ncaws hauv chav kuaj, yuav tsum hnav thaum lub sijhawm sim. Tsis txhob nqus cov hmoov los yog cov tshuaj, tsis txhob sib cuag nrog cov tawv nqaij thiab qhov muag. Thaum muaj kev sib chwv tsis sib haum, yaug tam sim nrog dej ntau thiab nrhiav kev pab kho mob. Xyuas kom tseeb tias nws yog siv nyob rau hauv ib puag ncig kev sim nyab xeeb thiab khaws cia kom zoo kom tsis txhob muaj xwm txheej.