N-Boc-N'-tosyl-D-histidine (CAS # 69541-68-0)
Taw qhia
Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) yog ib yam tshuaj uas muaj cov khoom nram qab no:
Xwm:
1. Cov tsos: dawb khoom
2. Cov mis mos molecular: C21H25N3O6S
3. Molecular Luj: 443.51
4. Melting point: txog 110-115 ° C
Siv:
Boc-D-Nws (Tos)-OH feem ntau yog siv hauv cov organic synthesis raws li pab pawg tiv thaiv D-histidine (D-Nws). Nws cov kev siv tseem ceeb suav nrog:
1. Nyob rau hauv cov synthesis ntawm ib tug polypeptide, nws yog siv los ua ib tug synthesis ntawm polypeptide ib theem zuj zus uas muaj ib pab pawg neeg D-histidine tiv thaiv.
2. Siv los ua ib qho nruab nrab hauv kev siv tshuaj chemistry rau kev sib txuas ntawm cov tshuaj lom neeg lub hom phiaj.
3. Tsim thiab tsim cov tshuaj sib xyaw ua ke hauv kev tshawb fawb.
Txoj Kev Npaj:
Kev npaj ntawm Boc-D-Nws (Tos)-OH feem ntau yog ua los ntawm cov kauj ruam hauv qab no:
1. D-histidine (D-His) tau tshwm sim nrog p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) muab D-histidine p-toluenesulfonyl (D-His-Tos).
2. Nyob rau hauv alkaline tej yam kev mob, D-His-Tos yog reacted nrog n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) los tsim Boc-D-Nws (Tos)-OH.
Cov ntaub ntawv kev nyab xeeb:
Kev soj ntsuam kev nyab xeeb ntawm Boc-D-His (Tos)-OH yog txwv, tab sis raws li cov tshuaj lom neeg, cov kev xav txog kev nyab xeeb hauv qab no yuav tsum raug sau tseg:
1. Tsis txhob nqus pa, tiv nrog daim tawv nqaij thiab qhov muag. Hnav cov khoom tiv thaiv tus kheej tsim nyog, xws li hnab looj tes thiab tsom iav.
2. Kev kuaj xyuas zoo yuav tsum tau ua raws li kev siv thaum lub sij hawm siv thiab kev ua pa zoo yuav tsum tau ua kom ntseeg tau.
3. Khaws rau hauv lub thawv kaw, kom deb ntawm hluav taws thiab oxidant.
4. Ua raws li cov cai thiab cov lus qhia cuam tshuam thaum ua tiav.
Thaum siv Boc-D-His (Tos)-OH, thov nco ntsoov ua raws li cov cai tswj kev nyab xeeb hauv chav kuaj thiab cov lus qhia ua haujlwm, thiab khaws cia thiab tswj cov tshuaj zoo. Yog tias tsim nyog, nws raug nquahu kom ua haujlwm raws li kev qhia ntawm cov kws tshaj lij.
