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N-Cbz-L-Threonine (CAS # 19728-63-3) Featured duab
  • N-Cbz-L-Threonine (CAS # 19728-63-3) 1

N-Cbz-L-Threonine (CAS # 19728-63-3)

Chemical Property:

Molecular Formula C12H15NO5
Molar Mass 253.25 Nws
Qhov ntom 1.2499 (kev kwv yees kwv yees)
Melting Point 101-103 ° C (lit.)
Boling Point 396.45 ° C (kwv yees kwv yees)
Kev sib hloov tshwj xeeb (α) -4.7 º (c = 4, acetic acid)
Flash Point 261.3°C dej
Solubility yuav luag pob tshab hauv Methanol
Vapor Siab 3.7E-11mmHg ntawm 25 ° C
Qhov tshwm sim Dawb mus rau lub teeb daj crystal hmoov
Xim Dawb mus Yuav luag dawb
BRN 2335409 ib
pKa 3.58 ± 0.10 (Kev kwv yees)
Kev cia khoom Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C
Refractive Index -4.9 ° (C = 2, AcOH)
MDL TIAB SA 00065948
Siv Siv rau biochemical reagents, peptide synthesis.

Product Detail

Khoom cim npe

Risk thiab Safety

Hazard Cov Cim Xn – Ua phem
Risk Codes R20/21/22 - Ua phem los ntawm kev nqus pa, tiv thaiv daim tawv nqaij thiab yog tias nqos.
R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij.
Kev nyab xeeb piav qhia S22 - Tsis txhob nqus plua plav.
S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
S36 - Hnav khaub ncaws tiv thaiv zoo.
S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
WGK Germany 3
HS Code 29242990 ib

 

 

N-Cbz-L-Threonine (CAS # 19728-63-3) Cov ntaub ntawv

kev npaj Ntxiv 50mL ntawm L-Thr (30mmol) thiab txias saturated Na2CO3 tov rau hauv 250mL tshuaj tiv thaiv lub raj mis, thiab do thiab yaj nyob rau hauv ib da dej dej khov. Tso 20mL ntawm Z-OSu (39.4mmol) acetone tov rau hauv lub raj mis tshuaj tiv thaiv; Do cov tshuaj tiv thaiv ntawm 25 ℃, TLC-UV fluorescence thiab ninhydrin xim txoj kev saib xyuas cov txheej txheem tshuaj tiv thaiv. Tom qab cov tshuaj tiv thaiv, ntxiv H2O20mL, extract nrog Et2O (30mL × 2) ntawm pH> 9, sau cov theem aqueous, kho cov pH rau 3 ~ 4 nrog 1.5NHCl, extract nrog EtOAc (30mL × 3), muab cov organic theem, ntxuav nrog saturated NaCl tov (25mL × 2), qhuav nrog anhydrous Na2SO4, xyuas qhov purity los ntawm TLC-ultraviolet fluorescence thiab ninhydrin xim txoj kev loj hlob, thiab evaporate nyob rau hauv lub siab txo, nqus kom qhuav kom tau ib tug yellowish oily kua N-benzyloxycarbonyl-L-threonine, uas yog khaws cia nyob rau hauv qis kub.
Siv CBZ-L-threonine yog N-Cbz tiv thaiv daim ntawv ntawm L-threonine (T405500). L-threonine yog ib qho tseem ceeb amino acid thiab feem ntau yog siv los ua khoom noj thiab khoom noj ntxiv. Kev hloov pauv ntawm Escherichia coli ua rau L-threonine ntau ntau rau kev tshawb fawb thiab khoom noj khoom haus lub hom phiaj. L-threonine yog ib txwm muaj nyob rau hauv cov ntses thiab nqaij qaib thiab tau muab tso rau hauv qee qhov ntawm lub cev cov proteins tseem ceeb, xws li hemoglobin thiab insulin.
Siv rau biochemical reagents thiab peptide synthesis.

 

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