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Nicorandil (CAS # 65141-46-0) Featured duab
  • Nicorandil (CAS # 65141-46-0) 1

Nicorandil CAS Nr .: 65141-46-0

Chemical Property:

Molecular Formula C8H9N3O4
Molar Mass 211.17 Nws
Qhov ntom 1.4271 (zeeg)
Melting Point 92 ° C
Boling Point 350.85 ° C (kwv yees kwv yees)
Flash Point 230 ° C
Solubility DMSO:> 10 mg/mL. Soluble nyob rau hauv methanol, ethanol, acetone los yog glacial acetic acid, me ntsis soluble nyob rau hauv chloroform los yog dej, yuav luag insoluble nyob rau hauv ether los yog benzene.
Vapor Siab 1.58E-08mmHg ntawm 25 ° C
Qhov tshwm sim Dawb mus rau dawb zoo li crystalline hmoov
Xim dawb mus dawb
Merck 14,6521 ib
Kev cia khoom 2-8 ° C
Refractive Index 1.7400 (kwv yees)
MDL TIAB SA 00186520
Physical thiab Chemical Properties Dawb crystalline hmoov, tsis muaj ntxhiab los yog tsw ntxhiab me ntsis, iab. Soluble nyob rau hauv methanol, ethanol, acetone los yog acetic acid, me ntsis soluble nyob rau hauv chloroform los yog dej, ob peb tsis yaj nyob rau hauv ether los yog benzene. Melting point 88.5-93.5 ° C. Mob toxicity LD50 nas (mg/kg): 1200-1300 qhov ncauj, 800-1000 tso rau hauv.
Siv Rau kev tiv thaiv kab mob plawv, angina pectoris
Kev tshawb nrhiav hauv vitro Nicorandil (100 mM) nce flavoprotein oxidation, tab sis tsis cuam tshuam rau daim nyias nyias tam sim no, rov kho cov mitoK (ATP) thiab surfaceK (ATP) channels ntawm qhov siab tshaj 10-fold. Nicorandil txo cov cell tuag hauv cov qauv ischemic granulation, cov nyhuv cardioprotective uas yog thaiv los ntawm mitoK (ATP) channel blocker 5-hydroxydecanoic acid tab sis tsis yog los ntawm surfaceK (ATP). Cov nyhuv ntawm channel blocker HMR1098. Nicorandil (100 mM) inhibits qhov poob ntawm TUNEL positivity, cytochrome C translocation, caspase-3 activation, thiab mitochondrial membrane muaj peev xwm (Delta (Psi) (m)). Kev tshuaj xyuas cov hlwb uas muaj fluorescence Delta (Psi) (m) - qhov taw qhia, tetramethylrhodamine ethyl ester (TMRE) los ntawm fluorescence activated cell sorter qhia tau tias, nicorandil tiv thaiv Delta (Psi) (m) depolarization nyob rau hauv ib qho concentration-dependent yam (EC(50) ) kwv yees li 40 mM, saturation 100 mM). Hauv ob lub hlwb hloov pauv, Nicorandil tau qhib qhov tsis muaj zog sab hauv kho, glibenclamide-sensitive 80 pS K channel. Hauv HEK293T hlwb, Nicorandil nyiam qhib K (ATP) channel uas muaj SUR2B. Nicorandil (100 mM) cuam tshuam ntau lub hlwb hauv TUNEL-zoo nuclei thiab nce 20 mM h2o2-induced caspase-3 kev ua haujlwm. Nicorandil concentration-dependently tiv thaiv kev poob ntawm DeltaPsim induced los ntawm H2O2.
Hauv vivo kawm Nicorandil (2.5 mg / kg txhua hnub, po) ua ke nrog Amlodipine (5.0 mg / kg txhua hnub, po) peb hnub ntawm kev ua tau zoo tiv thaiv kev hloov pauv thiab rov ua haujlwm enzyme rau qib ze rau cov nas ib txwm.

Product Detail

Khoom cim npe

Hazard Cov Cim Xn – Ua phem
Risk Codes R22 - Ua phem yog tias nqos
R41 - Riam phom loj rau qhov muag
Kev nyab xeeb piav qhia S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob.
S39 - Hnav qhov muag / ntsej muag tiv thaiv.
WGK Germany 3
RTECS ua 4667600
HS Code 293339 0
Toxicity LD50 hauv nas (mg / kg): 1200-1300 qhov ncauj; 800-1000 iv (Nagano)

 

Taw qhia

Nicolandil, tseem hu ua nicorandil amine, yog ib qho organic compound. Cov hauv qab no yog kev qhia txog cov khoom, kev siv, kev npaj thiab kev nyab xeeb ntawm nicorandil:

 

Zoo:

- Nicorandil yog cov xim tsis muaj xim crystalline uas yog soluble hauv dej thiab cov kuab tshuaj organic.

- Nws yog ib qho alkaline compound uas tuaj yeem hnov ​​​​mob nrog cov kua qaub los tsim cov ntsev sib txuas.

- Nicorandil ruaj khov hauv huab cua, tab sis tuaj yeem decompose thaum raug kub.

 

Siv:

- Nicolandil kuj tuaj yeem siv rau hauv kev sib txuas ntawm cov organic synthesis catalysts, photosensitizers, thiab lwm yam.

 

Txoj kev:

- Nicolandil feem ntau yog npaj los ntawm cov tshuaj tiv thaiv ntawm dimethylamine thiab 2-carbonyl compounds.

- Cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv alkaline tej yam kev mob thiab cov cua kub cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv ib tug haum hnyav.

 

Cov ntaub ntawv kev nyab xeeb:

- Nicorandil kuj muaj kev nyab xeeb rau tib neeg nyob rau hauv cov xwm txheej.

- Txawm li cas los xij, yuav tsum tau saib xyuas kom tsis txhob muaj kev sib cuag ncaj qha nrog lub qhov muag, tawv nqaij, thiab ua pa.

- Hnav cov khoom tiv thaiv tus kheej tsim nyog (PPE) xws li tsom iav kev nyab xeeb, hnab looj tes thiab cov cuab yeej ua pa.

- Thaum siv lossis khaws cia nicorandil, yuav tsum tau saib xyuas kom tsis txhob muaj hluav taws kub thiab kub kub.

 

  • Yav dhau los:
  • Tom ntej:
    • Sau koj cov lus ntawm no thiab xa tuaj rau peb

    cov khoom muaj feem xyuam