(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS # 19777-66-3)
Risk thiab Safety
| Risk Codes | R36/37/38 - Kab mob rau qhov muag, ua pa thiab tawv nqaij. R23/24/25 – Toxic los ntawm inhalation, nyob rau hauv kev sib cuag nrog daim tawv nqaij thiab yog hais tias nqos. |
| Kev nyab xeeb piav qhia | S26 - Thaum sib cuag nrog lub qhov muag, yaug tam sim ntawd nrog dej txaus thiab nrhiav kev kho mob. S36 - Hnav khaub ncaws tiv thaiv zoo. S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg ua tau.) S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag. |
| WGK Germany | 3 |
| FLUKA BRAND F CODE | 10-21 |
| HS Code | 29212900 ib |
(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS # 19777-66-3) Cov ntaub ntawv
| Txheej txheem cej luam | (S)-(-)-diaminopropane dihydrochloride tuaj yeem siv los ua cov tshuaj synthesis nruab nrab, xws li kev npaj ntawm Dexrazoxane, nws yog dextrorotatory enantiomer ntawm antitumor tshuaj razoxane. Rau cov tshuaj tiv thaiv lub plawv, chaw kho mob rau Kev Tiv Thaiv ntawm anthracycline anticancer tshuaj tshwm sim los ntawm lub plawv toxicity thiab leukemia nyob rau hauv cov me nyuam vim tshuaj kho mob los ntawm lub plawv puas, feem ntau raws li ib tug adjuvant nyob rau hauv kev kho mob ntawm cancer. |
| Siv | (S)-(-)-diaminopropane Dihydrochloride yog cov organic nruab nrab, nws tuaj yeem npaj tau los ntawm reacting D-(-)-tartaric acid thiab propylenediamine. Cov diamine tau siv rau hauv kev sib txuas ntawm chiral imidazoline compounds |
| kev npaj | Kev npaj ntawm (S)-(-)-diaminopropane dihydrochloride: ntxiv 30.0gD-(-)-tartaric acid thiab 8.0 ml dej thiab g(±)-1, 2-propanediamine nyob rau hauv cov tshuaj tiv thaiv hwj, do kom yaj, txias, ntxiv Dropwise, qhov kub tau nce mus rau reflux rau 2 teev nrog nplawm. Lub nplawm tau nres, thiab qhov kub tau nce mus rau 80 ° C. Rau 1 teev. Tom qab ntawd, qhov kub thiab txias tau maj mam txo mus rau hauv chav tsev kub, nqus lim, thiab lub tshuab nqus tsev kom qhuav kom tau 16.1g ntawm (S)-1, 2-propanediamine ditartrate. Ntxiv 16.1g ntawm (S)-1, 2-propanediamine ditartrate thiab dej rau cov tshuaj tiv thaiv lub khob, yaj nrog cua sov, thiab ces ntxiv ib tug tov ntawm 7.43g ntawm poov tshuaj chloride thiab 20ml dej, qhov sib tov yog stirred ntawm 70 ° C. rau 2h. Tom qab txias, lub tub yees tau tso cai sawv ntsug rau crystallization. Cov filtrate tau lim nrog suction thiab distilled kom qhuav nyob rau hauv lub siab txo kom 84% G ntawm daj khoom (3), yield 4.02, [α]20D =-°(C = 1%, H2O). |
Sau koj cov lus ntawm no thiab xa tuaj rau peb
