Sodium nitroprusside dihydrate (CAS # 13755-38-9)

Chemical Property:

Molecular Formula	C5H4FeN6Na2O3
Molar Mass	297.95 ib
Qhov ntom	1.72 ib
Dej Solubility	Soluble hauv dej. Me ntsis soluble ethanol.
Solubility	Soluble hauv dej (400 g / l) ntawm 20 ° C, thiab ethanol (me ntsis soluble).
Qhov tshwm sim	Sib sib zog nqus liab crystal
Specific Gravity	1.72 ib
Xim	Ruby liab
Exposure Limit	ACGIH: TWA 1 mg/m3 NIOSH: IDLH 25 mg/m3; TWA 1 mg/m3
Merck	14, 8649 ib
PH	5 (50g / l, H2O, 20 ℃)
Kev cia khoom	2-8 ° C
rhiab heev	Hygroscopic
MDL	TIAB SA 00149192
Physical thiab Chemical Properties	Liab-xim av crystalline hmoov, tsw ntxhiab; Tasteless.
Siv	Nws yog siv los ua reagent rau kev txiav txim siab ntawm aldehydes, acetone, sulfur dioxide, zinc, alkali hlau, sulfides, thiab lwm yam.
Kev tshawb nrhiav hauv vitro	Sodium Nitroprusside yog ib qho zoo vasodilator. Sodium nitroprusside muaj cov txiaj ntsig zoo vasodilatory hauv cov hlab ntsha thiab venules. Sodium Nitroprusside lov nyob rau hauv txoj kev mus tso nitric oxide (NO). TSIS MUAJ activates guanylate cyclase hauv vascular du nqaij thiab nce intracellular cGMP ntau lawm. Qhov no nws thiaj li ua rau kom so ntawm vascular du nqaij, uas dilates cov hlab ntsha. Sodium nitroprusside txo qhov proliferation ntawm vascular du nqaij.
Hauv vivo kawm	Sodium nitroprusside (5 mg / kg) raws li tus neeg pub khoom noj nitric oxide ua rau txo cov plab hnyuv ischemia-reperfusion raug mob hauv nas.

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Product Detail

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Risk thiab Safety

Risk Codes	R25 - Toxic yog nqos R26/27/28 - Cov tshuaj lom heev los ntawm kev nqus pa, tiv tauj nrog daim tawv nqaij thiab yog tias nqos.
Kev nyab xeeb piav qhia	S45 - Thaum muaj xwm txheej lossis yog tias koj tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia daim ntawv lo thaum twg ua tau.) S36/37/39 - Hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes thiab tiv thaiv qhov muag / ntsej muag. S22 - Tsis txhob nqus plua plav.
UN IDs	UN 3288 6.1/PG 3
WGK Germany	3
RTECS	lwj 8925000
FLUKA BRAND F CODE	3
TSCA	Yog lawm
HS Code	28372000 ib
Hazard Class	6.1
Packing Group	III
Toxicity	LD50 qhov ncauj hauv Luav: 99 mg / kg

13755-38-9 - Ib

Kev siv

Qhia ntxiv

1. Tian, Ya-Qin, et al. "Kev sib piv ntawm cov txheej txheem sib txawv thiab kev ua kom zoo ntawm microwave-pab extrac…

13755-38-9 - Lus Qhia

Soluble hauv dej, me ntsis soluble hauv cawv. Nws cov tshuaj aqueous tsis ruaj khov thiab tuaj yeem maj mam decompose thiab tig ntsuab.

13755-38-9 - Cov ntaub ntawv siv

kev taw qhia	sodium nitroprusside (molecular mis: Na2 [Fe (CN) 5NO] · 2H2O, tshuaj lub npe: sodium nitroferricyanide dihydrate) yog ib tug ceev-acting thiab luv-acting vasodilator, uas yog siv nyob rau hauv kev kho mob thaum muaj xwm ceev kub kub xws li kub siab ntsoog, hypertensive encephalopathy, malignant hypertension, paroxysmal hypertension ua ntej thiab tom qab phais pheochromocytoma, thiab lwm yam, nws kuj tuaj yeem siv rau tswj hypotension thaum phais tshuaj loog.
nyhuv	sodium nitroprusside yog ib qho muaj zog vasodilator ceev ceev, uas muaj kev cuam tshuam ncaj qha rau ntawm cov hlab ntsha thiab cov leeg nqaij leeg, thiab txo qis peripheral vascular tsis kam los ntawm dilating cov hlab ntsha. Vascular dilation kuj tseem tuaj yeem txo cov load ua ntej thiab tom qab lub plawv, txhim kho cov hlab plawv, thiab txo cov ntshav rov qab thaum lub valve tsis raug kaw, kom cov tsos mob ntawm lub plawv tsis ua haujlwm tuaj yeem txo qis.
qhia	1. nws yog siv rau thaum muaj xwm ceev hypotension ntawm hypertensive xwm txheej ceev, xws li hypertensive ntsoog, hypertensive encephalopathy, malignant hypertension, paroxysmal hypertension ua ntej thiab tom qab pheochromocytoma phais, thiab kuj yuav siv tau rau kev tswj hypotension thaum phais tshuaj loog. 2. Rau mob plawv tsis ua hauj lwm, nrog rau mob pulmonary edema. Nws kuj yog siv rau mob plawv tsis ua hauj lwm hauv mob myocardial infarction lossis thaum lub valve (mitral lossis aortic valve) tsis raug kaw.
pharmacokinetics	ncav cuag cov ntshav siab tshaj plaws tam sim ntawd tom qab tso dej tawm, thiab nws qib nyob ntawm qhov koob tshuaj. Cov khoom no yog metabolized los ntawm cov qe ntshav liab rau hauv cyanide, cyanide hauv lub siab yog metabolized rau hauv thiocyanate, thiab cov metabolite tsis muaj vasodilating kev ua haujlwm; cyanide tuaj yeem koom nrog hauv cov metabolism ntawm vitamin B12. Cov khoom no ua haujlwm yuav luag tam sim ntawd tom qab kev tswj hwm thiab mus txog qhov kawg ntawm kev ua, thiab tswj tau li 1 ~ 10 feeb tom qab tso dej tso tawm. Lub neej ib nrab ntawm cov neeg mob uas lub raum ua haujlwm tsis zoo yog 7 hnub ( ntsuas los ntawm thiocyanate), lub sijhawm ntev thaum lub raum ua haujlwm tsis zoo lossis ntshav sodium tsawg dhau, thiab nws tawm los ntawm lub raum.
Ib txheej txheem hluavtaws rau kev npaj	sodium nitroprusside, suav nrog cov kauj ruam hauv qab no: 1) Synthesizing tooj liab nitroso ferrocyanide: ntxiv qhov tsim nyog ntawm cov dej huv kom yaj cov poov tshuaj nitroso-ferricyanide hauv lub tank crystallization, cua sov rau 70-80 ℃ kom yaj tag, thiab maj mam ntxiv tooj liab sulfate pentahydrate aqueous tov dropwise, tom qab cov tshuaj tiv thaiv yog cia sov rau 30 feeb, centrifuge, lub centrifuged lim ncuav mog qab zib (tooj liab nitroso ferricyanide) tau muab tso rau hauv lub tank crystallization. 2) Synthetic sodium nitroprusside (sodium nitronitroferricyanide): Npaj saturated sodium bicarbonate aqueous tov raws li pub piv, thiab maj mam muab tso rau hauv nitroso ferricyanide ntawm 30-60 degrees C. Tom qab cov tshuaj tiv thaiv, centrifuge, sau filtrate thiab tshuaj pleev ib ce. 3) Concentration thiab crystallization: Cov khoom filtrate thiab lotion tau muab tso rau hauv lub tshuab nqus tsev concentration, thiab glacial acetic acid maj mam ntxiv dropwise kom txog thaum tsis muaj npuas tshwm sim. Tig lub tshuab nqus tsev twj tso kua mis thiab kub txog li 40-60 ° C, pib concentration, mloog zoo rau ntau cov crystals los nag, kaw lub qhov cub valve, lub tshuab nqus tsev vacuum los npaj rau crystallization. 4) Centrifugal ziab: tom qab crystallization, cov supernatant raug tshem tawm, cov muaju sib npaug sib npaug thiab centrifuged, lub ncuav mog qab zib lim tau muab tso rau hauv lub phaj stainless hlau, thiab cov khoom tau los ntawm lub tshuab nqus tsev kom qhuav.
biological kev ua	Sodium Nitroprusside yog lub vasodilator muaj zog uas ua haujlwm los ntawm kev tso tawm NO hauv cov ntshav.
Hom phiaj	Tus nqi
Siv	Siv los ua reagent rau kev txiav txim siab ntawm aldehydes, ketones, sulfides, zinc, sulfur dioxide, thiab lwm yam. Siv los ua reagent rau kev txiav txim siab ntawm aldehydes, acetone, sulfur dioxide, zinc, Alkali hlau, sulfides, thiab lwm yam. Vasodilators. Kev txheeb xyuas ntawm aldehydes thiab ketones, zinc, sulfur dioxide thiab alkali hlau sulfides. Chromatic tsom xam, kuaj zis.