Tom ntej: tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS # 845267-78-9)

Molecular Formula	C10H15NO4
Molar Mass	213.23 Nws
Qhov ntom	1.199 ib
Boling Point	373.8 ± 35.0 ° C (Predicted)
Flash Point	179.9°C dej
Vapor Siab	8.72E-06mmHg ntawm 25 ° C
pKa	10.67 ± 0.20 (Tshaj tawm)
Kev cia khoom	Khaws nyob rau hauv qhov chaw tsaus, kaw hauv qhuav, Chav Kub
Refractive Index	1.493 ib
MDL	PIB 10566071

Product Detail

Risk Codes	20/21/22 - Ua phem los ntawm kev nqus pa, tiv nrog daim tawv nqaij thiab yog tias nqos.
Kev nyab xeeb piav qhia	S23 - Tsis txhob ua pa. S24/25 - Tsis txhob sib cuag nrog daim tawv nqaij thiab qhov muag.
WGK Germany	3
HS Code	29337900 ib

Siv	2, 4-dipiperidon-1-formate tert-butyl formate yog cov synthesis ntawm phenoxymethyl-dihydrothiazolopyridone derivatives Reactants nyob rau hauv cov khoom, raws li ib tug xaiv zoo qauv modulator (PAM) ntawm metabolized glutamate 5 (mGlu5) receptor.
daim ntawv thov	2, 4-dioperidone-1-tert-butyl formate feem ntau yog siv los ua cov organic nruab nrab thiab cov tshuaj nruab nrab, thiab tuaj yeem siv rau hauv kev tshawb fawb thiab kev loj hlob ntawm cov txheej txheem tshuaj thiab tshuaj synthesis txheej txheem.
kev npaj	Kauj ruam a: ntxiv EDCI (191.7g) rau DMF (400mL) tov ntawm 3-(tert-butoxycarbonylamino) propionic acid (189.2g, 1.0mol), meldamic acid (144.1g, 1.0mol) thiab DMAP (135.0g, 1.1mol) ) txias los ntawm dej khov da dej, 1.0mol). Qhov tshwm sim reactants tau nplawm ib hmos ntawm chav tsev kub. Cov tshuaj tiv thaiv yog quenched nrog 200mL H2O. Qhov sib xyaw ua ke tau ntxiv dropwise rau H2O (2.0L) nyob rau hauv cov neeg kho tshuab stirring. Cov khoom tau raug lim thiab ntxuav kom huv si nrog dej rau pH 7 kom tau txais cov khoom (283g, 90% tawm los). Kauj Ruam B: Kev daws ntawm 3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl)-3-oxopropylcarbamate tert-butyl ester (100g, 317.46mmol) hauv toluene (1500mL) yog rhuab ntawm 100 ° C rau 4 teev. Cov reactants yog txias rau chav tsev kub thiab concentrated nyob rau hauv lub siab txo kom tau ib tug crude khoom. Cov khoom (56g, 83% tawm los) yog purified los ntawm MTBE-sib tsoo.